Fig 6. Venn diagram analyses of genes with differential methylation patterns after PARylation inhibition.

These analyses show that some genes are commonly modulated by PARylation inhibition. Interestingly, most of them are differentially modified at different genomic regions of the gene. For instance a particular gene is hypermethylated at the promoter region while it is hypomethylated within the gene body. The function of such differential patterns remains to be elucidated.