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. 2015 Aug 25;10(8):e0135700. doi: 10.1371/journal.pone.0135700

Fig 6. Schematic diagram showing the probable mechanism through which prenatal alcohol modulates ILK and affects plasticity.

Fig 6

ILK may affect an unknown amino acid phosphorylation which may help in GluR2 receptor internalization. Reduced ILK activity may reduce the target phosphorylation and stabilize GluR2 at the surface thereby increase GluR2 at the synapse. Increased GluR2 and downstream active GSK3β may reduce LTP induction and maintenance. The probable cause of reduced ILK activity could be less mature BDNF availability in the brain of animals prenatally exposed to alcohol.