Table 1. Normalized scores of various docking programs and molecular descriptors.
Compounds | pIC50 | Goldscores | Chem Score | AutoDock score | Auto Dock Vina Score | DOCK6 Grid Score | ASP Score | LogP | TPSA | Vol | Nrotb | Consensus score |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 5.46 | 0.19 | 0.33 | 0.12 | 0.55 | 0.67 | 0.48 | 0.47 | 0.95 | 0.88 | 0.6 | 1.54 |
2 | 4.10 | 0.22 | 0.47 | 0.74 | 0.75 | 0.12 | 0.16 | 0.04 | 0.13 | 0.00 | 0.2 | 1.60 |
3 | 4.66 | 0.28 | 0.54 | 0.26 | 0.70 | 0.01 | 0.24 | 0.01 | 0.73 | 0.00 | 0.2 | 1.76 |
4 | 4.80 | 0.31 | 0.50 | 0.40 | 0.75 | 0.07 | 0.22 | 0.08 | 0.73 | 0.08 | 0.2 | 1.78 |
5 | 5.37 | 0.00 | 0.23 | 0.80 | 0.50 | 0.08 | 0.00 | 0.57 | 0.20 | 0.38 | 0.33 | 0.73 |
6 | 5.59 | 0.40 | 0.16 | 1.00 | 0.60 | 0.13 | 0.24 | 0.24 | 0.20 | 0.16 | 0.27 | 1.40 |
7 | 5.00 | 0.08 | 0.15 | 0.79 | 0.35 | 0.20 | 0.01 | 0.46 | 0.20 | 0.30 | 0.33 | 0.59 |
8 | 5.17 | 0.21 | 0.00 | 0.55 | 0.15 | 0.18 | 0.06 | 0.58 | 0.20 | 0.44 | 0.47 | 0.42 |
9 | 5.00 | 0.44 | 0.52 | 0.20 | 0.90 | 0.61 | 1.00 | 0.90 | 0.40 | 0.82 | 0.8 | 2.86 |
10 | 5.19 | 1.00 | 0.12 | 0.27 | 0.45 | 0.80 | 0.57 | 0.45 | 0.78 | 0.58 | 0.87 | 2.14 |
11 | 5.00 | 0.60 | 0.15 | 0.04 | 0.00 | 0.56 | 0.33 | 0.55 | 0.78 | 0.46 | 0.87 | 1.08 |
12 | 5.66 | 0.91 | 0.36 | 0.05 | 0.25 | 1.00 | 0.75 | 0.79 | 0.78 | 0.84 | 1 | 2.27 |
13 | 5.00 | 0.34 | 0.56 | 0.51 | 0.25 | 0.30 | 0.28 | 0.16 | 0.40 | 0.10 | 0.53 | 1.43 |
14 | 5.00 | 0.46 | 0.59 | 0.38 | 0.65 | 0.68 | 0.49 | 0.29 | 0.54 | 0.40 | 0.8 | 2.18 |
15 | 5.15 | 0.51 | 0.84 | 0.39 | 0.00 | 0.46 | 0.37 | 0.53 | 0.40 | 0.43 | 0.73 | 1.72 |
16 | 5.00 | 0.51 | 1.00 | 0.00 | -0.05 | 0.91 | 0.68 | 0.54 | 0.43 | 0.64 | 0.87 | 2.14 |
17 | 9.05 | 0.57 | 0.65 | 0.34 | 0.80 | 0.21 | 0.21 | 0.51 | 1.00 | 0.51 | 0 | 2.23 |
18 | 6.49 | 0.37 | 0.35 | 0.32 | 0.85 | 0.00 | 0.50 | 0.48 | 0.14 | 0.04 | 0.2 | 2.07 |
19 | 6.74 | 0.24 | 0.42 | 0.36 | 1.00 | 0.01 | 0.51 | 0.52 | 0.00 | 0.09 | 0.2 | 2.17 |
20 | 7.46 | 0.24 | 0.77 | 0.28 | 0.75 | 0.19 | 0.34 | 0.63 | 0.00 | 0.13 | 0.2 | 2.10 |
21 | 6.03 | 0.59 | 0.63 | 0.15 | 0.55 | 0.04 | 0.51 | 0.00 | 0.38 | 0.02 | 0.07 | 2.28 |
22 | 7.48 | 0.54 | 0.67 | 0.17 | 0.60 | 0.00 | 0.41 | 0.44 | 0.19 | 0.18 | 0.07 | 2.22 |
23 | 8.40 | 0.61 | 0.81 | 0.13 | 0.80 | 0.06 | 0.65 | 0.36 | 0.19 | 0.15 | 0.07 | 2.87 |
24 | 7.51 | 0.54 | 0.73 | 0.08 | 0.60 | 0.05 | 0.60 | 0.37 | 0.19 | 0.15 | 0.07 | 2.47 |
25 | 7.66 | 0.40 | 0.62 | 0.78 | 1.00 | 0.32 | 0.77 | 1.00 | 0.20 | 0.90 | 0.4 | 2.79 |
26 | 8.30 | 0.40 | 0.76 | 0.77 | 0.80 | 0.51 | 0.73 | 0.96 | 0.20 | 0.92 | 0.47 | 2.70 |
27 | 8.10 | 0.41 | 0.74 | 0.80 | 0.90 | 0.44 | 0.75 | 0.97 | 0.34 | 1.00 | 0.4 | 2.80 |
After data normalization and calculation of consensus score, correlation coefficient between the activity (pIC50) and the consensus score was calculated. It was compared with correlation coefficient of all docking programs.