Skip to main content
. 2015 Aug 25;11(8):e1005437. doi: 10.1371/journal.pgen.1005437

Fig 8. Model for morphogenesis of the regeneration epidermis.

Fig 8

After initial wound closure, fgf20a is induced at the epithelial-mesenchymal boundary by 6 hours post-amputation. fgf20a signaling then contributes to induction of expression of the lamb1a paralog in the adjacent epithelial cell layer to establish a basement membrane and to polarize the basal cell layer. This polarization is essential for positioning signaling receptors and induction of morphogenetic factors that guide osteoblast patterning and bone formation.