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. 2015 Jul 31;2(7):618–628. doi: 10.18632/oncoscience.178

Figure 3. TCGA-19-2624 appears to contain a population of chromothripsis-derived regions that facilitate the amplification of EGFR, MDM2, and CDK4.

Figure 3

(A) Circos diagram depicting all suspect chromothriptic regions resulting from Shatterproof analysis. (B) Enhancement of the chromosome 7 and 12 recombination seen in 3a supporting the assertion that EGFR, along with MDM2 and CDK4, have been translocated onto the same amplicon. (C) FISH performed on paraffin embedded tissue from TCGA-19-2624 reveals that both EGFR and MDM2 are present at numerous loci within the nucleus, consistent with the formation of double minutes.