Fig. 1.

Effect of RAPA on performance in tests of motor function. (a) pole test; (b) forepaw stepping adjustment test; (c) accelerating rotarod test. Age-matched WT and TG mice were fed mouse diet containing microencapsulated RAPA or the microencapsulation material Eudragit S100 (Vehicle Control) from 13 weeks of age for 24 weeks. Data represent mean±SEM. Data were analyzed using a mixed-effect regression model. *p<0.05, WT control versus WT RAPA; **p<0.05, WT control versus TG control; ***p<0.05, TG control versus TG RAPA.