Table 4.
Cluster coordinates and statistics for longitudinal grey matter volumetric change
| Anatomical area | Cytoarchitectonic area (%)a | MNI peak coordinates (mm) | Extent (voxels) | Central tendency | TFCE score | p value (FWE) | ||
|---|---|---|---|---|---|---|---|---|
| x | y | z | ||||||
| Grey matter expansion: subcortical cluster | ||||||||
| Mediodorsal thalamus | Th-temporal (16.6) | 8 | −12 | 10 | 1,847 | 1.75 | 3,399 | .0001 |
| Th-prefrontal (12.2) | 1.20 | |||||||
| Caudate nucleus | Caudate head (n. a.) | 10 | 12 | 2 | n.a. | 2,420 | .0004 | |
| Grey matter expansion: cortical cluster | ||||||||
| Precentral gyrus | Area 6 (85.3) | 36 | −20 | 62 | 182 | 2.22 | 951 | .0293 |
| Precentral gyrus | Area 4a (19.6) | 5 | −28 | 75 | 2.41 | 890 | .0375 | |
| Grey matter contraction: cerebellar cluster | ||||||||
| Cerebellum |
Lobulus VI (23.8) Lobulus VIIa (11.2) |
−26 | −56 | −16 | 497 | 1.44 | 927 | .0307 |
FWE Family-wise error corrected, n.a. not assigned in histological atlas, MNI Montreal Neurological Institute, TFCE Threshold-free cluster enhancement, Th-temporal/prefrontal Thalamus with preferential connections to the temporal/prefrontal cortex
aPercentage overlap of cluster with cytoarchitectonic probabilistic area (only overlaps >10 % are reported)