Fig. 3.

Biomarker profiles plots for a patient with acute kidney injury (AKI) according to the most severe pRIFLE stratum reached by the patient during PICU admission (pRFILEmax). This patient reached the pRIFLEmax Injury (I) stratum at day 7 after admission to the PICU. Black filled circles/lines eCCl (mL/min/1.73 m²), red filled squares/lines biomarker levels. a cystatin-C (Cys-C; mg/L), b plasma neutrophil gelatinase-associated lipocalin (pNGAL; ng/mL), c urinary NGAL (uNGAL; ng/mg Cr), d kidney injury molecule-1 (KIM-1; pg/mg Cr). Note that the period of AKI is given on the top right of each plot. As eCCl declines over time, the level of each of biomarker increases