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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2015 May 1;14(8):1951–1961. doi: 10.1158/1535-7163.MCT-15-0066

Fig. 3. Breast cancer tumor-initiating cells express functionally active vitamin D receptor.

Fig. 3

A, FACS sorting schema for purification of CD49fhiEpCamlow MMTV-Wnt-1 TIC-enriched cells. B–D, VDR functional responses in breast cancer TICs. Sorted CD49fhiEpCamlow TIC cells were treated with 1 nM calcitriol (Cal) for 16 h and mRNA levels of Vdr, Cyp24, and Cyp27b1 were determined by qRT-PCR (n = 3; *** p<0.01 as compared to the CON group; ND, not detected). Values represent mean ± SEM.