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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2015 May 1;14(8):1951–1961. doi: 10.1158/1535-7163.MCT-15-0066

Fig. 4. Calcitriol inhibits the self-renewal of breast cancer tumor-initiating cells.

Fig. 4

A, Representative images and bar graphs showing that calcitriol treatment (vehicle or 0.1, 1, 10, and 100 nM) decreased the spheroid forming abilities of TICs in a dose dependent manner (n = 3; ** P < 0.01 and *** P < 0.001 as compared to the control). B, Calcitriol treatment (at 1 nM) in primary culture reduced the spheroid formation in secondary culture (n = 3; *** P < 0.001 as compared to white bar and + P < 0.001 as compared to dotted bar). C, Analysis of combined treatment of TICs with calcitriol (10 nM) and 2 Gy of ionizing radiation (n = 3; P < 0.05). Values represent mean ± SEM.