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. Author manuscript; available in PMC: 2015 Aug 26.
Published in final edited form as: Expert Opin Drug Deliv. 2014 Jun;11(6):901–915. doi: 10.1517/17425247.2014.902047

Figure 4. Typical Transwell® transport study setup and experimental data is shown.

Figure 4

(A) Diagram of a Caco-2 monolayer grown onto a Transwell system to study the transport of therapeutics. The drug is delivered apically and samples are collected from the basolateral chamber. (B) Typical data from an experiment aiming to increase protein transport across the epithelium are presented. Insulin (●) is transported less effectively than insulin in the presence of P(MAA-g-EG) microparticles (■), whereas insulin conjugated to transferrin (▲) outperformed both due to transferrin receptor-mediated transcytosis.

Reproduced with permission from [130].

P(MAA-g-EG): Poly(methacrylic acid) grafted with poly(ethylene glycol).