FIG. 5.

Pathway annotations associated with CS exposure. The DEGs of the CS-exposed versus air-exposed samples at a FDR of ≤ 0.01 were uploaded to DAVID. Canonical pathway of the KEGG database was annotated in the datasets using the DAVID annotation tool at a p-value of < .05. The KEGG pathways that were categorized under the ‘human diseases’ category were excluded. The different colors designate the p-value annotations. Abbreviations: BR, bronchial epithelial cell monoculture; BRF, bronchial epithelial cell and fibroblast coculture; sBR, isolated/scraped bronchial epithelial cells from the coculture; DEG, differentially expressed genes; KEGG, Kyoto Encyclopedia of Genes and Genomes.