Fig. 3.

Anti Ang-2 antibody treatment does not alter pre-existing atherosclerosis in the aortic root. Representative images of HE-stained plaques in the aortic root (A + B) show no difference in plaque size (C) or necrotic core (D) in pre-existing plaques of the aortic root after antibody treatment. Also, collagen (percentage of Sirius Red positive area/total plaque, E–G), macrophage content (Mac3+ area/total plaque area, H–J) and adventitial microvessel density (microvessels/mm2, K–M) were not altered by the anti-Ang-2 antibody treatment. Representative pictures: left panels control IgG, right panels anti-Ang-2. IgG n = 12; anti-Ang-2 n = 14.