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Advanced lesions in the carotid arteries are not affected by Ang-2 blockage. Representative images of HE-stained collar induced advanced plaques (A + B) in the right common carotid artery. Plaque size (C) necrotic core (D). Representative images and quantification of (E–G) collagen, (H–J) macrophages, (K–M) microvessels: left control IgG, right anti-Ang-2. IgG n = 12; anti-Ang-2 n = 14.
