Table 1.
Parameter | Tissue | Alteration in anti-Ang-2 mice | Statistics | |
---|---|---|---|---|
Plaque burden | Plaque size | Brachiocephalic artery | ↓ | * |
Collar model | = | n.s. | ||
Aortic root | = | n.s. | ||
Degree of stenosis | Brachiocephalic artery | ↓ | ** | |
Plaque phenotype | Necrotic core | Brachiocephalic artery | Absent in fatty streak | – |
Collar model | = | n.s. | ||
Aortic root | = | n.s. | ||
Plaque collagen | Brachiocephalic artery | = | n.s. | |
Aortic root | = | n.s. | ||
Plaque macrophages | Brachiocephalic artery | = | n.s. | |
Aortic root | = | n.s. | ||
Microvessel density | Brachiocephalic artery | = | n.s. | |
Aortic root | = | n.s. | ||
Systemic effects | Angiopoetin-2 | Plasma | ↑ | ** |
Cholesterol | Plasma | = | n.s. | |
Triglycerides | Plasma | ↓ | * | |
Cardiac function | US of the heart | = | n.s. | |
Carotid strain + shear stress | US of carotid artery | = | n.s. | |
Body weight | Before sacrifice | = | n.s. |
US = ultra sound; n.s. = not significant.
*p < 0.05, **p < 0.01.