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. 2015 Aug 26;35(34):12018–12032. doi: 10.1523/JNEUROSCI.5151-14.2015

Figure 5.

Figure 5.

OPCs that were null for GluR2 or deficient in αv integrin did not accelerate their migration rate in response to AMPA in P4 cerebellum. A, Time-lapse images of OPC migration in P4 cerebellum from GluR2−/− PLP-EGFP mouse. Yellow asterisks mark the soma of OPC. The elapsed time is indicated above each image. Application of AMPA (2 μm) did not accelerate the migration of GluR2−/− OPCs. Scale bar, 15 μm. B, Sequential changes in the total distance and calculated speed traveled during each 30 min of the testing period by the OPC soma shown in A were plotted as a function of elapsed time before and after application of 2 μm AMPA. C, Time-lapse images representing OPC migration in the cerebellum of P4 αv integrin+/− PLP-EGFP mice. Application of AMPA (2 μm) did not accelerate the migration of αv integrin+/− OPCs. Scale bar, 10 μm. D, Sequential changes in the total distance and average calculated speed traveled during each 30 min of the testing period by the OPC soma shown in C were plotted as a function of elapsed time before and after application of 2 μm AMPA.