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. 2014 Aug 1;14(10):1–64.

Table A2:

Studies Reviewed in OCT Monitoring Strategies for A-VEGF Treated n-AMD

Authors Title Publication
Abraham P, Yue H, Wilson L Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 2 Am J Ophthalmol. 2010 Sep;150(3):315–24
Antoszyk AN, Tuomi L, Chung CY, Singh A. FOCUS Study Group Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration (FOCUS): year 2 results Am J Ophthalmol. 2008 May;145(5):862–74
Bandukwala T, Muni RH, Schwartz C, Eng KT, Kertes PJ Effectiveness of intravitreal ranibizumab for the treatment of neovascular age-related macular degeneration in a Canadian retina practice: A retrospective review Can J Ophthalmol. 2010;45(6):590–5
Bolz M, Simader C, Ritter M, Ahlers C, Benesch T, Prunte C, et al Morphological and functional analysis of the loading regimen with intravitreal ranibizumab in neovascular age-related macular degeneration Br J Ophthalmol. 2010;94(2):185–9
Boyer DS, Heier JS, Brown DM, Francom SF, Ianchulev T, Rubio RG A Phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration Ophthalmology. 2009;116(9):1731–9
Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY, et al Ranibizumab versus verteporfin for neovascular age related macular degeneration N Engl J Med. 2006 Oct 5;355(14):1432
Brown DM, Michels M, Kaiser PK, Heier JS, Sy JP, Ianchulev T Ranibizumab versus verteporfin photodynamic therapy for neovascular age related macular degeneration: Two year results of the ANCHOR study Ophthalmology. 2009 Jan;116(1):57
Carneiro AM, Mendonca LS, Falcao MS, Fonseca SL, Brandao EM, Falcao-Reis FM Comparative study of 1+PRN ranibizumab versus bevacizumab in the clinical setting Clin Ophthalmol. 2012;6(1):1149–57
Chakravarthy U, Harding SP, Rogers CA, Downes SM, Lotery AJ, Wordsworth S, et al Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial Ophthalmology. 2012 Jul;119(7):1399–41
Cohen SY, Dubois L, Tadayoni R, Fajnkuchen F, Nghiem-Buffet S, Delahaye-Mazza C, et al Results of one-year's treatment with ranibizumab for exudative age-related macular degeneration in a clinical setting Am J Ophthalmol. 2009 Sep;148(3):409–13
Cohen SY, Oubraham H, Uzzan J, Dubois L, Tadayoni R Causes of unsuccessful ranibizumab treatment in exudative age-related macular degeneration in clinical settings Retina. 2012 Sep;32(8):1480–5
Dadgostar H, Ventura AA, Chung JY, Sharma S, Kaiser PK Evaluation of injection frequency and visual acuity outcomes for ranibizumab monotherapy in exudative age-related macular degeneration Ophthalmology. 2009 Sep;116(9):1740–7
El-Mollayess GM, Mahfoud Z, Schakal AR, Salti HI, Jaafar D, Bashshur ZF Fixed-interval versus OCT-guided variable dosing of intravitreal bevacizumab in the management of neovascular age-related macular degeneration: a 12-month randomized prospective study Am J Ophthalmol. 2012;153(3):481–9
Ernst BJ, Barkmeier AJ, Akduman L Optical coherence tomography-based intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration Int Ophthalmol. 2010 Jun;30(3):267–70
Fung AE, Lalwani GA, Rosenfeld PJ, Dubovy SR, Michels S, Feuer WJ, et al An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration Am J Ophthalmol. 2007 Apr;143(4):566–83
Fung AT, Kumar N, Vance SK, Slakter JS, Klancnik JM, Spaide RS, et al Pilot study to evaluate the role of high-dose ranibizumab 2.0 mg in the management of neovascular age-related macular degeneration in patients with persistent/recurrent macular fluid <30 days following treatment with intravitreal anti-VEGF therapy (the LAST Study) Eye. 2012;26:1181–7
Gerding H, Loukopoulos V, Riese J, Hefner L, Timmermann M Results of flexible ranibizumab treatment in age-related macular degeneration and search for parameters with impact on outcome Graefes Arch Clin Exp Ophthalmol. 2011 May;249(5):653–62
Heier JS, Boyer DS, Ciulla TA, Ferrone PJ, Jumper JM, Gentile RC, et al Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: year 1 results of the FOCUS Study Arch Ophthalmol. 2006 Nov;124(11):1532–42
Heier JS, Brown DM, Chong V, Korobelnik JF, Kaiser PK, Nguyen QD, et al Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration Ophthalmology. 2012 Dec;119(12):2537–48
Heimes B, Lommatzsch A, Zeimer M, Gutfleisch M, Spital G, Dietzel M, et al Long-term visual course after anti-VEGF therapy for exudative AMD in clinical practice evaluation of the German reinjection scheme Graefes Arch Clin Exp Ophthalmol. 2011 May;249(5):639–44
Holz FG, Amoaku W, Donate J, Guymer RH, Kellner U, Schlingemann RO, et al Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: The SUSTAIN study Ophthalmology. 2011;118(4):663–71
Kaiser PK, Boyer DS, Cruess AF, Slakter JS, Pilz S, Weisberger A Verteporfin plus ranibizumab for choroidal neovascularization in age-related macular degeneration: twelve-month results of the DENALI study Ophthalmology. 2012 May;119(5):1001–10
Kang S, Roh YJ One-year results of intravitreal ranibizumab for neovascular age-related macular degeneration and clinical responses of various subgroups Jpn J Ophthalmol. 2009 Jul;53(4):389–95
Katz G, Giavedoni L, Muni R, Evans T, Pezda M, Wong D, et al Effectiveness at 1 year of monthly versus variable-dosing intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to age-related macular degeneration Retina. 2012;32(2):293–8
Krebs I, Vecsei M, V, Bodenstorfer J, Glittenberg C, Ansari SS, Ristl R, et al Comparison of Ranibizumab monotherapy versus combination of ranibizumab with photodynamic therapy with neovascular age-related macular degeneration Acta Ophthalmol. 2013 May;91(3):e178–e183
Krebs I, Schmetterer L, Boltz A, Told R, Vecsei-Marlovits V, Egger S, et al A randomised double-masked trial comparing the visual outcome after treatment with ranibizumab or bevacizumab in patients with neovascular age-related macular degeneration. Br J Ophthalmol. 2013 Mar;97(3):266–71
Kruger FM, Kemp H, Sorensen TL Four-year treatment results of neovascular age-related macular degeneration with ranibizumab and causes for discontinuation of treatment Am J Ophthalmol. 2013 Jan;155(1):89–95
Kumar A, Sahni JN, Stangos AN, Campa C, Harding SP Effectiveness of ranibizumab for neovascular age-related macular degeneration using clinician-determined re-treatment strategy Br J Ophthalmol. 2011;95(4):530–3
Lalwani GA, Rosenfeld PJ, Fung AE, Dubovy SR, Michels S, Feuer W, et al A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study J Ophthalmol. 2009 Jul;148(1):43–58
Larsen M, Schmidt-Erfurth U, Lanzetta P, Wolf S, Simader C, Tokaji E, et al Verteporfin plus ranibizumab for choroidal neovascularization in age-related macular degeneration: twelve-month MONT BLANC study results Ophthalmology. 2012 May;119(5):992–1000
Li X, Hu Y, Sun X, Zhang J, Zhang M, Neovascular Age-Related Macular Degeneration Treatment Trial Using Bevacizumab (NATTB) Bevacizumab for neovascular age-related macular degeneration in China Ophthalmology. 2012;119(10):2087–93
Martin DF, Maguire MG, Ying GS, Grunwald JE, Fine SL, Jaffe GJ Ranibizumab and bevacizumab for neovascular age-related macular degeneration N Engl J Med. 2011 May 19;364(20):1897–908
Martin DF, Maguire MG, Fine SL, Ying GS, Jaffe GJ, Grunwald JE, et al Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results Ophthalmology. 2012 Jul;119(7):1388–98
Michalova K, Wickremasinghe SS, Tan TH, Chang A, Harper CA, Downie JA, et al Ranibizumab treatment for neovascular age-related macular degeneration: from randomized trials to clinical practice Eye. 2009 Aug;23(8):1633–40
Muether PS, Hoerster R, Hermann MM, Kirchhof B, Fauser S Long-term effects of ranibizumab treatment delay in neovascular age-related macular degeneration Graefes Arch Clin Exp Ophthalmol. 2013 Feb;251(2):453–8
Muniraju R, Ramu J, Sivaprasad S Three-year visual outcome and Injection frequency of intravitreal ranibizumab therapy for neovascular age-related macular degeneration Ophthalmologica. 2013 Apr 30;230(1):27–33
Oubraham H, Cohen SY, Samimi S, Marotte D, Bouzaher I, Bonicel P, et al Inject and extend dosing versus dosing as needed: a comparative retrospective study of ranibizumab in exudative age-related macular degeneration Retina. 2011 Jan;31(1):26–30
Regillo CD, Brown DM, Abraham P, Yue H, Ianchulev T, Schneider S, et al Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1 Am J Ophthalmol. 2008 Feb;145(2):239–48
Rothenbuehler SP, Waeber D, Brinkmann CK, Wolf S, Wolf-Schnurrbusch UE Effects of ranibizumab in patients with subfoveal choroidal neovascularization attributable to age-related macular degeneration Am J Ophthalmol. 2009 May;147(5):831–7
Rudnisky CJ, Liu C, Ng M, Weis E, Tennant MT Intravitreal bevacizumab alone versus combined verteporfin photodynamic therapy and intravitreal bevacizumab for choroidal neovascularization in age-related macular degeneration: visual acuity after 1 year of follow-up Retina. 2010 Apr;30(4):548–54
Schmidt-Erfurth U, Eldem B, Guymer R, Korobelnik JF, Schlingemann RO, Axer-Siegel R, et al Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: the EXCITE study Ophthalmology. 2011;118(5):831–9
Silva R, Axer-Siegel R, Eldem B, Guymer R, Kirchhof B, Papp A, et al The SECURE study: long-term safety of ranibizumab 0.5 mg in neovascular age-related macular degeneration Ophthalmology. 2013 Jan;120(1):130–9
Singer MA, Awh CC, Sadda S, Freeman WR, Antoszyk AN, Wong P, et al HORIZON: an open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration Ophthalmology. 2012 Jun;119(6):1175–83
Soderberg A-C, Algvere PV, Hengstler JC, Soderberg P, Seregard S, Kvanta A Combination therapy with low-dose transpupillary thermotherapy and intravitreal ranibizumab for neovascular age-related macular degeneration: A 24-month prospective randomised clinical study Br J Ophthalmol. 2012;96(5):714–8
Subramanian ML, Abedi G, Ness S, Ahmed E, Fenberg M, Daly MK, et al Bevacizumab vs ranibizumab for age-related macular degeneration: 1-year outcomes of a prospective, double-masked randomised clinical trial Eye. 2010;24(11):1708–15
Williams PD, Callanan D, Solley W, Avery RL, Pieramici DJ, Aaberg T A prospective pilot study comparing combined intravitreal ranibizumab and half-fluence photodynamic therapy with ranibizumab monotherapy in the treatment of neovascular age-related macular degeneration Clin Ophthalmol. 2012;6(1):1519–25
Ying G-S, Huang J, Maguire MG, Jaffe GJ, Grunwald JE, Toth C, et al Baseline predictors for one-year visual outcomes with ranibizumab or bevacizumab for neovascular age-related macular degeneration Ophthalmology. 2013;120(1):122–9