#	Searches	Results
1	exp Retinal Diseases/ use mesz	91346
2	exp retina disease/ use emez	164020
3	exp Choroidal Neovascularization/ use mesz	3590
4	exp subretinal neovascularization/ use emez	6130
	((macul* adj2 (degenerat* or edema*)) or (age-relat* adj2 maculopath*) or choroidal
5	neovascularis* or retinopath* or uveitic maculopath* or central serous retinopath* or epiretinal membrane*).ti,ab.	92977
6	(diabet* adj4 (macul* or retin*)).ti,ab.	37763
7	exp Macular Edema/ use mesz	3669
8	exp Diabetes Mellitus/ use mesz	287906
9	and/7–8	1516
10	or/1–6,9	276766
11	exp Tomography, Optical Coherence/ use mesz	10441
12	exp optical coherence tomography/ use emez	16148
13	(optical coherence adj5 tomograph*).ti,ab.	22967
14	((spectral or fourier) adj2 domain*).ti,ab.	6037
15	(CIRRUS or SPECTRALIS or FD?OCT or 3D OCT?1000 or RTVue or SOCT or OCT?SLO or oct).mp.	35011
16	or/11–15	51117
17	10 and 16	14101
18	Meta Analysis.pt.	36965
19	Meta Analysis/ use emez	68704
20	Systematic Review/ use emez	57019
21	exp Technology Assessment, Biomedical/ use mesz	8791
22	Biomedical Technology Assessment/ use emez	11436
	(meta analy* or metaanaly* or pooled analysis or (systematic* adj2 review*) or published
23	studies or published literature or medline or embase or data synthesis or data extraction or cochrane).ti,ab.	301636
24	((health technolog* or biomedical technolog*) adj2 assess*).ti,ab.	3949
25	exp Random Allocation/ use mesz	76124
26	exp Double-Blind Method/ use mesz	117322
27	exp Control Groups/ use mesz	1362
28	exp Placebos/ use mesz	31199
29	Randomized Controlled Trial/ use emez	336510
30	exp Randomization/ use emez	60645
31	exp Random Sample/ use emez	4554
32	Double Blind Procedure/ use emez	112949
33	exp Triple Blind Procedure/ use emez	37
34	exp Control Group/ use emez	41699
35	exp Placebo/ use emez	212212
36	(random* or RCT).ti,ab.	1410151
37	(placebo* or sham*).ti,ab.	454141
38	(control* adj2 clinical trial*).ti,ab.	39002
39	exp Practice Guideline/ use emez	285300
40	exp Professional Standard/ use emez	275062
41	exp Standard of Care/ use mesz	620
42	exp Guideline/ use mesz	23122
43	exp Guidelines as Topic/ use mesz	102366
44	(guideline* or guidance or consensus statement* or standard or standards).ti.	222163
45	(controlled clinical trial or meta analysis or randomized controlled trial).pt.	455842
46	or/18–45	3028958
47	17 and 46	1178
48	limit 47 to english language	1060
49	limit 48 to yr=“2008 -Current”	788
50	remove duplicates from 49	535