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Regulatory SS risk variants were subdivided into three groups: promoters (polymerase II binding), enhancers (H3k27Ac, H3k36me3, and/or H3k7me3 binding), and insulators (CTCF binding). Regulatory SS risk variants were further located according to the protein-coding gene, and the predominant transcription factor associated with each SS risk variant is indicated (NF-κB, STATs, and Egr1).
