Table 1.

Gene risk factors associated with primary Sjögren’s syndrome (SS).

SS gene risk factors extracted from the literature
BAK1, BCL2, BLK, C4A, CCL2, CD14, CD40, CD40LG, CHRM3, CXCR5, EBF1, FAM167A, GTF2I, HLA DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, ICA1, IKBKE, IL10, IL12A, IL17F, IL21, IRF5, LILRA3, LTA*, MBL2, NCR3, NFKB1, OR2B11, PKN1*, PTPN22, SLC25A40, STAT1, STAT4, TNF, TNFA1P3, TNFSF13B, TNIP1*, TNPO3, TNFSF4, Trim21
New genes in high linkage disequilibrium
ABCB1, AC053545.3, ADAD1, AF213884.2, APBB3, ATP6V1G2, ATP6V1G2-DDX39B, BTNL2, C6orf10, CCL11, CCL7, CTD-2049J23.2, DBF4, GGNBP1, HCG23, HLA-DPA1, IL2, KIAA1109, MCCD1*, Metazoa_SRP, MIR4752, NDUFA2, NFKBIL1, PTGER1, RP11-10J5.1, RP11-356I2.2, RP11-356I2.4, RP3-527F8.2, RP5-998H6.2, RSBN1, RUNDC3B, SLC25A40, snoU13, XXbac-BPG254F23.7

Bold missense mutations.

*Missense mutations detected by linkage disequilibrium.