Figure 2. During effector CD8⁺ T cell differentiation, expression of CXCR3 is downregulated in an IL-12 dependent manner.

CD62L and KLRG1 surface expression (A) and CXCR3 surface expression (B) on total CD8⁺ T cells were assessed by flow cytometry 7 days post-vaccination. Data represent 3–4 independent experiments with 4–5 mice per group per experiment. Mean ± SEM, data were analyzed using unpaired t test, and Holms-Sidak post-hoc test, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.

DOI: http://dx.doi.org/10.7554/eLife.09017.006