Figure 9. Schematic depicting the sequence of events leading to the generation of late-stage KLRG1⁺ effector CD8⁺ T cells.

1: While in the white pulp, CD8α⁺ DCs activate CD8⁺ T cells causing the upregulation of CXCR3 expression. 2: CXCR3^Hi CD62L^Lo CD8⁺ T cells outmigrate towards RP and begin to proliferate. 3: Upon outmigration through bridging channels, CXCR3^Hi CD62L^Lo CD8⁺ T cells continue to proliferate in clusters found in the MZ. 4: Exposure to IL-12 produced by mDCs in the MZ/RP areas induces KLRG1 upregulation. 5: Subsequent exposure to IFN-γ and IFN-γ-inducible chemokines downregulate CXCR3 expression on RP-localized KLRG1⁺ effector CD8⁺ T cells.

DOI: http://dx.doi.org/10.7554/eLife.09017.015