Table 2.
Serum concentrations of acute-phase proteins in male and female Göttingen minipigs of different ages
| Male |
Female |
|||||||
| 6 wk | 16 wk | 24 wk | 40–48 wk | 6 wk | 16 wk | 24 wk | 40–48 wk | |
| CRP,b μg/mL | 5.77 (4.42–7.19) | 7.21 (4.59–21.35) | 5.50 (2.27–10.02) | 3.63 (2.84–13.45) | 12.2 (5.87–17.75) | 3.28 (2.59–6.12) | 10.18 (5.83–15.80) | 8.47 (6.58–17.85) |
| Haptoglobin,c μg/mL | 6145.6 (4653.8– 7070.8) | 305.3 (21.4– 1440.6) | 248.9 (13– 1165.7) | 34.7 (13– 2203.1) | 7294.0 (4795.7–8783.8) | 2284.1 (1821.0– 3220.2) | 2521.0 (1733.9– 3693.6) | 3018.4 (1634.6–4082.3) |
| PMAP,c μg/mL | 1021.0 (771.6– 1270.3) | 708.0 (554.0– 901.6) | 682.5 (583.4– 976.5) | 740.4 (609.8–1107.8) | 792.7 (588.9– 1229.3) | 157.4 (129.5– 173.5) | 247.0 (192.5– 491.8) | 184.2 (140.3– 209.5) |
| PAGP,d,e μg/mL | 344.2 (251.5–530.3) | 409.6 (344.9–472.6) | 329.5 (264.0–380.4) | 287.0 (227.0–413.9) | 545.2 (305.2–640.8) | 563.7 (457.3–771.8) | 298.5 (222.8–443.2) | 413.0 (316.3–556.6) |
| Albumin,a g/L | 44.3 (42.7–49.8) | 41.8 (40.7–48.2) | 50.7 (45.6–54.3) | 48.6 (38.4–58.7) | 44.4 (41.9–55.5) | 49.1 (43.9–56.5) | 46.4 (44.4–58.7) | 68.1 (55.5–73.8) |
CRP, C-reactive protein; PAGP, porcine α-1 acid glycoprotein; PMAP, pig major acute-phase protein.
Values are expressed as median with interquartile range (n = 15). All dependent variables were log transformed. Intergroup differences were evaluated by two-way ANOVA (sex, age and the interaction between the two as factors) followed by Tukey's multiple-comparison test. Significant effect of age × sex: aP < 0.05, bP < 0.01, cP < 0.001; dsignificant (P < 0.001) effect of age; esignificant (P < 0.001) effect of gender.
Because most values for serum amyloid A were below the lower limit of quantification (31.25 µg/mL), no statistical analysis was performed.