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. 2015 Aug 26;5:13194. doi: 10.1038/srep13194

Figure 2. Interaction assay between NA and active Ganoderma triterpenoids.

Figure 2

(a) Molecular surface of NA (09H1N1, PDB ID: 3TI6) with bound oseltamivir (red), ganoderic acid T-Q (yellow), or ganoderic acid TR (black). (b) Molecular surface of NA (H5N1, PDB ID: 2HU0) with bound oseltamivir (red), ganoderic acid T-Q (yellow), or ganoderic acid TR (black). Ligplots showing key hydrophobic and hydrogen-bonding contacts between NA (H5N1, PDB ID: 2HU0) and ganoderic T-Q (c) or ganoderic acid TR (d). The red circles indicate the same residues involved in interaction of NA with oseltamivir. (e) Lineweaver-Burk plot of inhibition of NA (H5N1) by ganoderic acid T-Q. Kic and Kiu are the EI and ESI dissociation constants, respectively. (f) Sequence alignment between the NA subtypes and the residues in the binding pocket of NA to ganoderic acid T-Q. Matching residues were showed as dots and the gaps were showed as dashes. The red color indicates the H-bond residues, while the green color indicates the hydrophobic residues.