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. 2015 Aug 26;5:12804. doi: 10.1038/srep12804

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Copyright © 2015, Macmillan Publishers Limited

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Hexose transport activity of wild-type (GLUT_wt) and mutant GLUTs was measured by entrance counter-flow transport assay. Each point is the average of three measurements and error bars represent standard deviations. Line shows non-linear fit for IC₅₀ calculation. “glu” represents glucose transport; “fru” represents fructose transport. (a) Comparison of glucose and fructose transport of GLUT1_wt, GLUT1_W388A, GLUT5_wt, GLUT5_A396W. All measurements were normalized to GLUT5_wt fructose transport as 100%. Blank spaces represent assays in which no transport activity was measureable. (b) Concentration-dependent Rub inhibition of the relative transport activity mediated by GLUT1_W388A and GLUT5_A396W. (c) Concentration-dependent Ast6G inhibition of the relative transport activity mediated by GLUT1_W388A and GLUT5_A396W.