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. 2015 Aug 4;7(8):2906–2917. doi: 10.3390/toxins7082906

Figure 2.

Figure 2

Hindpaw withdrawal thresholds with heat stimulation after SNE and/or direct BoNT/A application onto the L4 DRG. (▲) short duration after BoNT/A application (n = 7); (○) without BoNT/A application (n = 4). Data are presented as mean ± S.E.M. of withdrawal thresholds to thermal stimulation. SNE reduced the withdrawal threshold, and direct BoNT/A application (14 days after the SNE) to the L4 DRG (100 pg in 100 µL ACSF) restored the threshold to the baseline level for both mechanical and thermal stimuli. * p < 0.05 statistical difference compared with baseline (two-way RM ANOVA with paired t-test).