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. 2015 Sep;1853(9):2158–2167. doi: 10.1016/j.bbamcr.2015.02.011

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — Effect of colonic CaSR on regulation of genes modulating proliferation, differentiation, and apoptosis in vivo. Colons sampled from CaSR^−/−/PTH^−/− (DKO) and CaSR^+/+/PTH^−/− (control) mice were investigated for gene expression. mRNA expression of CaSR (A). mRNA expression of the proliferation markers Orc1 (B), Cdc6 (C), Mcm2 (D), Mcm5 (E), Mcm6 (F) and Cdc45 (G). mRNA expression of differentiation marker, Si (H), and the pro-apoptotic marker, Bax (I). Individual data points are shown. Bars represent median ± SEM. Statistical significance was calculated using unpaired t-tests. n = 9 animals/group, *p < 0.05, ***p < 0.001.