Fig. 5.

Impact of a CaSR activator or inhibitor on cell viability, differentiation, and apoptosis in stably transfected Caco2-15 cells. (A) Proliferation (n = 4), (B) apoptosis (n = 4) and (C) differentiation (n = 3) were measured in Caco2-15^CaSR-WT, Caco2-15^CaSR-DN or the Caco2-15^EMP cells. Bars represent means ± SEM. Statistical significance was determined using ANOVA followed by Tukey's post-test. Asterisks above bars indicate significant differences within groups compared with the respective vehicle control (striped bars), whereas hash tags indicate significant differences between groups compared with Caco2-15^EMP cells. *p < 0.01, **p < 0.05, ***p < 0.001, ^#p < 0.01 and ^###p < 0.001.