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. 2015 Aug 6;10(1):1–23. doi: 10.1016/j.molonc.2015.07.005

Figure 2.

Figure 2

rLOX‐PP inhibits orthotopic growth and metastasis of human UMSCC2 oral cancer cells. UMSCC2 oral cancer cells expressing DsRed (Bais et al., 2015a) were transduced with a lentivirus expression vector for rLOX‐PP (n = 8) or empty vector (n = 9). Cells were respectively orthotopically injected into nude mice at 500,000 cells per mouse. (A) Caliper measurements were carried out at intervals and tumor volumes calculated. (B) In vivo imaging of tumor cells in mice was conducted at intervals. Data indicate that rLOX‐PP expression inhibited both primary tumor growth and formation of metastases. *p < 0.05, two way ANOVA with Bonferroni post hoc analysis.