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. 2015 Aug 6;10(1):1–23. doi: 10.1016/j.molonc.2015.07.005

Figure 14.

Figure 14

Schematic representation of different intracellular uptake pathways of rLOX‐PP‐Atto565. Postulated mechanisms of rLOX‐PP‐Atto565 uptake are shown and the cell lines which use a particular uptake mechanism are indicated. They include actin‐ and PI3K‐dependent macropinocytosis, dynamin‐clathrin‐dependent endocytosis and dynamin‐caveolae‐dependent endocytosis. The effect of pH change by EIPA, bafilomycin A1 and rLOX‐PP itself on subsequent rLOX‐PP‐Atto647N trafficking was shown. *rLOX‐PP‐Atto565 uptake in DU145 cell is not PI3K‐dependent macropinocytosis.