Table 2.

Additional inclusion and exclusion criteria for patients in Group C

Inclusion criteria for patients in Group C
1.	Bone marrow reserve adequate for chemotherapy (i.e. absolute neutrophil count (ANC) ≥ 1.5 × 109/l and platelet count ≥ 100 × 109/l)
2.	Adequate creatinine clearance defined as GFR ≥ 50 ml/min
Exclusion criteria for patients in Group C
1.	History of significant cardiac or other medical conditions that preclude the use of cisplatin and intravenous hydration
2.	Clinically significant hearing impairment sufficient to affect daily living and/or pre-existing tinnitus
3.	Pre-existing peripheral neuropathy that precludes the use of cisplatin
4.	Hypersensitivity to the active substance or other platinum compounds or to any of the other excipients
5.	Dehydrated condition