Table 1.
Association of clinico-pathological characteristics of ER+/HER2- breast cancer patients with levels of ING1 in the stroma
| Characteristics | # of cases (%) | ER+/Her2- | ||
|---|---|---|---|---|
| Low lng1 | High lng1 | P-value | ||
| Age | ||||
| < 53 | 72 (16.25) | 56 | 16 | 0.880 |
| ≥ 53 | 371 (83.75) | 284 | 87 | |
| Menopausal status | ||||
| Pre-menopausal | 26 (5.90) | 17 | 9 | |
| Peri-menopausal | 21 (4.70) | 18 | 3 | 0.231 |
| Post-menopausal | 321 (72.50) | 242 | 79 | |
| n/a (male) | 1 (0.20) | 1 | 0 | |
| Unknown | 74 (16.70) | 62 | 12 | |
| Stage | ||||
| I | 188 (42.40) | 148 | 40 | 0.365 |
| II | 138 (31.20) | 105 | 33 | |
| III | 36 (8.20) | 24 | 12 | |
| IV | 5 (1.10) | 3 | 2 | |
| Unknown | 76 (17.20) | 60 | 16 | |
| Tumor grade | ||||
| 1 | 103 (25.40) | 88 | 15 | 0.001 |
| 2 | 247 (60.80) | 195 | 52 | |
| 3 | 56 (13.80) | 31 | 25 | |
| Tumor size | ||||
| < 2 cm | 223 (53.86) | 179 | 44 | 0.020 |
| ≥ 2 cm | 191 (46.14) | 137 | 54 | |
| Lymph node status | ||||
| Negative | 278 (72.77) | 220 | 58 | 0.103 |
| Positive | 104 (27.23) | 74 | 30 | |
| Rx Tamoxifen | ||||
| No | 161 (37.44) | 118 | 43 | 0.196 |
| Yes | 269 (62.56) | 212 | 57 | |
The listed clinico-pathological characteristics were analyzed for their correlation with low/high levels of stromal ING1. Stromal ING1 shows a correlation with tumor grade and size in the ER+/ Her2- group of patients in the cohort