Table 2.

Multivariate analysis of disease free survival

Variable	Hazard ratio	P value	9 % CI
All patients
Tumor grade	2.741	< 0.001	1.618–4.647
Tumor size	1.431	0.188	0.840–2.437
Lymph node status	3.505	< 0.001	2.142–5.737
ER	0.360	0.010	0.165–0.785
HER2	1.669	0.391	0.518–5.383
Stromal 1NG1	2.125	0.004	1.270–3.557
ER+/HER2-patients
Tumor grade	2.447	0.002	1.374–4.358
Tumor size	1.401	0.236	0.802–2.446
Lymph node status	3.429	<0.001	2.014–5.839
Stromal 1NG1	2.320	0.002	1.356–3.969

Multivariate analysis of clinically relevant biomarkers along with stromal ING1. Stromal ING1 level is a significant and independent biomarker in the total population and ER+/HER2- sub-population in the Calgary Tamoxifen Cohort