Table III.
Multivariate hazard ratios and 95% confidence intervals for HA-CDI among specific cancer diagnoses.
| Exposure* | Full Cohort | ALL | AML | NHL | OS/EWS | CNS | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| N = 33,095 380 CDI |
N = 10,070 92 CDI |
N = 3,161 108 CDI |
N = 2,798 30 CDI |
N = 2,132 20 CDI |
N = 6,238 42 CDI |
||
|
| |||||||
| Race | White | Not Significant | reference
|
Not Significant | Not Significant | Not Significant | Not Significant |
| Black | 0.346 (0.081–1.478)
|
||||||
| Asian | 3.190 (1.390–7.309)
|
||||||
| American Indian | 0.700 (0.050–9.886)
|
||||||
| Other | 0.595 (0.182–1.951)
|
||||||
| Missing | 0.940 (0.556–1.589) | ||||||
|
| |||||||
| Sex | Male | 1.272 (1.034–1.565) | 1.701 (1.096–2.641) | Not Significant | Not Significant | Not Significant | Not Significant |
|
| |||||||
| Aminoglycoside | 1.357 (1.053 – 1.749) | 1.786 (1.079–2.956) | Not Significant | Not Significant | Not Significant | Not Significant | |
|
| |||||||
| Penicillins | Not Significant | Not Significant | Not Significant | Not Significant | Not Significant | 3.195 (1.056—9.671) | |
|
| |||||||
| 3rd Generation Cephalosporin | 1.518 (1.177 – 1.959) | Not Significant | Not Significant | Not Significant | 4.417 (1.230–15.860) | 2.306 (1.120–4.746) | |
|
| |||||||
| 4th Generation Cephalosporin | 2.383 (1.839 – 3.089) | 2.166 (1.306–3.592) | 2.272 (1.434–3.599) | Not Significant | 4.315 (1.272–14.635) | Not Significant | |
|
| |||||||
| Carbapenem | Not Significant | Not Significant | Not Significant | Not Significant | Not Significant | 3.123 (1.146–8.515) | |
|
| |||||||
| H2 Antagonist | 0.730 (0.584 – 0.912) | 0.554 (0.340–0.903) | Not Significant | Not Significant | Not Significant | Not Significant | |
|
| |||||||
| Proton Pump Inhibitor | 1.398 (1.096 – 1.784) | Not Significant | Not Significant | Not Significant | 4.095 (1.270–13.205) | Not Significant | |
|
| |||||||
| Disease Severity | No Ventilation, Pressor History
|
Not Significant | Not Significant | Not Significant | Not Significant | reference
|
Not Significant |
| Ventilation History
|
0.855 (0.154–4.744)
|
||||||
| Pressor History
|
3.724 (0.680–20.400)
|
||||||
| Ventilator & Pressor History | 34.969 (4.709– 259.703) | ||||||
|
| |||||||
| Chemotherapy 7d | Not Significant | Not Significant | Not Significant | Not Significant | Not Significant | 2.916 (1.435—5.925) | |
|
| |||||||
| Chemotherapy 8–14d | 1.942 (1.491 – 2.529) | 2.603 (1.317—5.147) | 2.248 (1.253—4.033) | Not Significant | Not Significant | Not Significant | |
ALL, Acute Lymphoblastic Leukemia; AML, Acute Myeloid Leukemia; NHL, Non-Hodgkins Lymphoma; OS/EWS, Osteosarcoma/Ewings Sarcoma; CNS, Central Nervous System tumors.
*
Results stratified by hospital site