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. Author manuscript; available in PMC: 2015 Aug 26.
Published in final edited form as: J Neurosurg. 2013 Oct 4;119(6):1415–1423. doi: 10.3171/2013.7.JNS1323

Figure 5. Conditioned Media (CM) from Malignant Glioma Stem-Like Cells Treated with Bortezomib induces Microvascular Endothelial Cell Growth due to VEGF Over-expression.

Figure 5

(A) Media conditioned for 72 hours by GSCs treated with bortezomib stimulates microvascular endothelial cell growth, while the conditioned media from the GSCs treated with both bortezomib and the VEGF neutralizing antibody, bevacizumab doesn’t increase endothelial cell growth. (B) Direct treatment of microvacular endothelial cells with with bortezomib (10 nM) as well as with bevacizumab (0.5mg/mL) caused a 40% reduction in microvascular endothelial cell viability, while the combined treatment caused a 60% decrease in cell viability, statistically superior to either drug alone.