Fig. 7.

Protection by caspase-7 knockout against ON crush-induced loss of RGC function. a Representative STR-ERG waveforms from WT (left panels) and Casp7 ^−/− (right panels) mice. Upper panels show the representative waveforms before ON crush and lower panels show the representative waveforms 28 d post crush. Blue lines represent the ON crushed left eyes and black lines represent the uninjured, contralateral (right) eyes. b pSTR amplitudes of ON crush and uninjured eyes of WT and Casp7 ^−/− mice at indicated time points. ON crush significantly decreased RGC function in a time-dependent fashion as shown as a decline in pSTR amplitudes, which was significantly ameliorated in the Casp7 ^−/− animals. Data are shown as mean ± SD (n = 6). *: p < 0.05 versus the respective uninjured control group, #: p < 0.05 versus the “WT (ON crush)” group by One-Way ANOVA then Tukey–Kramer post hoc test