Table 2.

Key practical aspects of the study with all the clinical visits and the requested exams

Visits	Screening	Visit 1	Visit 2	Visit 3
Weeks	−1	1	4	12
Informed consent	X
Inclusion and exclusion criteria	X	X
Medical history	X
Medical evaluation/physical examination	X	X	X	X
Randomization		X
Pregnancy test	X
Creatinine	X			X
Fasting glucose	X		X	X
Ultrasensitive C-reactive protein	X			X
Total cholesterol	X			X
High-density lipoprotein cholesterol	X			X
Triglycerides	X			X
Glycated hemoglobin	X			X
Alanine aminotransferase	X			X
Microalbuminuria	X			X
Ambulatory blood pressure monitoring		X		X
Treadmill test	X
Determination of the central aortic pressure and vascular stiffness markers		X		X
Endothelium function		X		X