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Steps involved in generating Biofilter SNP-SNP models. (A) Biofilter accessed LOKI-compiled databases with information about connections between genes (for the example shown here: connections within a pathway). (B) Biofilter-generated gene-gene models based on connections between genes that were validated by five or more databases. (C) For each gene-gene model, pairwise SNP-SNP models were created for each unique combination of loci across a gene pair.
