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. 2013 Jun 21;136(8):2432–2443. doi: 10.1093/brain/awt143

Figure 3.

Figure 3

Pioglitazone normalizes mitochondrial DNA and mitochondrial protein levels in spinal cords of Abcd1−/− mice. Wild-type (n = 8), Abcd1−/− (n = 8) and Abcd1−/− mice fed for 2 months with pioglitazone (Abcd1− + PIO) (n = 8) at 12 months of age. (A) Relative gene expression of iNOS and COX2, (B) mitochondrial DNA (mtDNA) level, (C) NDUFB8 and VDAC protein levels and (D) relative gene expression of PGC-1α, NRF1, TFAM and PPARα, PPARβ and PPARγ. Data represent mean ± SD (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001). WT = wild-type.