Table 1. Key uses and findings of Active Bacterial Core surveillance data for vaccine development, evaluation, and policy formulation*.
Pathogen | Vaccines | Key uses and findings |
---|---|---|
Streptococcus pneumoniae
|
PCV7 and PCV13 |
Selection of serotypes included in PCV7and PCV13 |
Informed ACIP recommendations for children <5 y of age | ||
Tracking postlicensure declines in cases | ||
Documented effectiveness of PCV7 | ||
Monitoring incidence of nonvaccine serotypes | ||
Accelerated regulatory approval of PCV13 | ||
Informed ACIP recommendations for PCV13 use in immunocompromised adults and children | ||
Neisseria meningitidis
|
Conjugate vaccines, serogroup B vaccines |
Informed ACIP recommendations for children 11–18 y of age |
Informed ACIP recommendations for booster dose | ||
Documented vaccine effectiveness | ||
Informed ACIP infant meningococcal recommendations | ||
Evaluated potential effect on serogroup B disease in United States | ||
Haemophilus influenzae
|
Hib vaccine |
Tracking postlicensure declines in Hib disease |
Tracking shift toward non-Hib disease; | ||
Evaluated effect of vaccine shortages | ||
Group A Streptococcus |
M-type vaccine
(under development) |
Estimated degrees of protection against severe group A streptococcal infections |
Group B Streptococcus |
Trivalent vaccine
(under development) |
Informing development of vaccine to prevent early-onset (within 1 week of life) group B streptococcal disease |
Methicillin-resistant Staphylococcus aureus | S. aureus vaccine (under development) | Determining population groups to target |
*ACIP, Advisory Committee on Immunization Practices; Hib, H. influenzae type b vaccine; PCV7, 7-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine. An expanded version of this table with references is available in the online Technical Appendix (http://wwwnc.cdc.gov/EID/article/21/9/14-1333-Techapp1.pdf).