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METH up-regulated the expression of PD-L1 and PD-1 in human neurons. Representative immunocytochemical staining of (A) PD-L1 and (B) PD-1, in human neurons with/without METH at 24 hrs and 48 hrs; Ranks-Kruskal-Wallis test for quantitative densitometric analysis of (C) PD-L1 and (D) PD-1 levels. **P≤0.01 and ****P≤0.0001 are the statistical significance compared with controls.
