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. Author manuscript; available in PMC: 2015 Aug 26.
Published in final edited form as: J Appl Toxicol. 2013 Mar 1;33(11):1193–1202. doi: 10.1002/jat.2861

Figure 2.

Figure 2

Gene expression profiling is more sensitive than the traditional toxicity endpoints. A single acute toxic dose of acetaminophen was administered to rats. At various time intervals ranging from 4 h to 1 week after administration of the chemical, blood was analyzed for toxicity based on the activities of aspartate transaminase (AST) and alanine transaminase (ALT) (A) and expression of marker genes for hepatotoxicity (B). Significant alterations in the expression of the selected hepatotoxicity marker genes were observed in the blood before any significant change in the activities of transaminases suggesting the superior sensitivity of gene expression changes as indicators of target organ toxicity (reproduced with permission from Molecular and Cellular Biochemistry 2010; 335: 223–234. *p<0.05 compared with time matched controls.