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. Author manuscript; available in PMC: 2016 Aug 15.
Published in final edited form as: Bioorg Med Chem. 2015 Mar 4;23(16):5144–5150. doi: 10.1016/j.bmc.2015.02.050

Figure 6. Relationship between 3D7 potency, metabolic stability and lipophilicity.

Figure 6

Figure 6

Figure 6

(A) Plot of Pf 3D7 potency as a function of CLogP. (B) Plot of Pf 3D7 potency versus metabolic stability in mouse, rat and human liver microsomes (MLM, RLM and HLM). (C) Plot of metabolic stability in liver microsomes as a function of CLogP.