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. Author manuscript; available in PMC: 2016 Aug 15.
Published in final edited form as: Bioorg Med Chem. 2015 Mar 4;23(16):5144–5150. doi: 10.1016/j.bmc.2015.02.050

Scheme 1.

Scheme 1

Reagents and Conditions: (a) KCN, (NH4)2CO3, aq. MeOH; (b) R3X, K2CO3, DMF; (c) NaH, R1X, DMF; (d) ArI, CuI, 2,2,6,6-tetramethyl-3,5-heptanedione, Cs2CO3; (e) HCl or TFA; (f) RCHO, Na(OAc)3BH, DMF; (g) RCO2H, EDC, HOBt, NEM, DCM; (h) R8Br, K2CO3, CH3CN.