Table 2. Multivariate models of effect of baseline C-reactive protein (CRP) on change in Unified Parkinson’s Disease Rating Scale Part III (UPDRS-III) score for the entire follow-up period, as estimated by a generalized estimation equation model.

Variable	B	95% CI	P
Model I
Baseline CRP
<0.7 mg/L (reference)	0
0.7 mg/L≤	1.78	0.51–3.06	0.006
Increment in LED
Per 100 mg/day increase	-0.23	-0.49–0.03	0.080
Model II
Baseline CRP
<0.7 mg/L (reference)	0
0.7 mg/L≤	1.41	0.21–2.61	0.021
Sex
Female (reference)	0
Male	1.40	0.30–2.51	0.013
Age
Per five years increase	0.84	0.53–1.16	<0.001
Baseline UPDRS-III score
Per five points increase	-1.37	-1.70–-1.04	<0.001
Dementia
No (reference)	0
Yes	0.85	-0.67–2.37	0.272
Increment in LED
Per 100 mg/day increase	-0.19	-0.44–0.06	0.132