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. 2015 Jul 20;7(4):1759091415592389. doi: 10.1177/1759091415592389

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© The Author(s) 2015

This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).

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Figure 3. — Positively charged coat traffics to oligodendrocytes in rat hippocampal slices. Positively charged PEG600-NH₂ coat behaves similar to CL1 with regard to neurons exhibiting extracellular staining in CA3 with some neuronal trafficking. Tellingly, it appears to associate with oligodendrocytes, which is the first of the QDs tested that does so without chondroitinase treatment. (a) PEG600NH₂ shows little specific uptake in neurons of the hippocampus with large amounts of extracellular dispersion as seen with CL1. (b) PEG600-NH₂ traffics into oligodendrocytes with little extracellular staining indicating specificity. (c) Typical CL4 distribution within neuronal cell bodies of the hippocampus. (d) CL4 does not target oligodendrocytes, which are stained green with MAB 1580. (e) Average red channel pixel intensity of PEG600-NH₂ and CL4 in oligodendrocytes showing over a twofold increase in trafficking with positively charged PEG600 (p < .005). Red represents QDs, green is cell-specific staining, and blue is DAPI. Arrows indicate regions of high QD uptake. PEG = polyethylene glycol; CL = compact ligand; QDs = quantum dots.