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. 2015 Jul 20;7(4):1759091415592389. doi: 10.1177/1759091415592389

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© The Author(s) 2015

This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).

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Figure 4. — Pretreatment with chondroitinase ABC digests the extracellular matrix. Chondroitinase ABC successfully digests chondroitin sulfate chains following an overnight application in hippocampal slices. (a) Positive staining for antibody to chondroitin-4-sulfate, produced after chondroitinase digestion, shows treatment paradigm is successful. (b) Antibody staining in untreated cells (negative control). (c) Cartoon representation of the proposed action of chondroitinase ABC on the oligodendrocyte cell-membrane. CL = compact ligand; QD = quantum dot.