Figure 5.

Chondroitinase ABC increases CL4 trafficking into oligodendrocytes. (a, c) 24-hr pretreatment of chondroitinase ABC (2 µM) to media of hippocampal cultures increases CL4 quantum dot uptake in oligodendrocytes. (b, d) Oligodendrocyte primary cultures after 24-hr chondroitinase ABC treatment show a similar increase in uptake (inset is an example control image of untreated culture). Red represents QDs, green is antioligodendrocyte staining (MAB 1580), and blue is DAPI. Asterisks indicate significant increase over untreated controls via Student’s independent t test (p < .005). CL = compact ligand; QDs = quantum dots; DAPI = 6-diamidino-2-phenylindole.