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. 2015 Aug 20;7(4):1759091415598290. doi: 10.1177/1759091415598290

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© The Author(s) 2015

This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — P75^NTR mRNA expression and apoptotic cell death levels in wild-type and mutant SORT1 cells. Gray columns represent untrasfected HEK293 cells, blue columns HEK293 cells transfected with SORT1 wild-type plasmid, and orange columns HEK293 cells transfected with SORT1 mutant plasmid. (a) Relative quantification of p75^NTR mRNA expression in untransfected and transfected HEK293 cells with either wild-type or mutant SORT1 alleles. The y-axis shows the relative expression of the target gene (P75^NTR) relative to the internal control gene (B2M) and the x-axis shows treated and untreated cells with different proNTs (10 ng/ml). (b) Percentage of apoptosis in untransfected and transfected wild-type and mutant SORT1 cells. The y-axis shows the percentage of cells in early apoptosis and the x-axis represents different proNT treatments. ***p < .01, **p < .05.