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. Author manuscript; available in PMC: 2015 Aug 26.
Published in final edited form as: Mucosal Immunol. 2008 Jan 16;1(2):131–138. doi: 10.1038/mi.2007.15

Figure 1. Association signal and linkage disequilibrium patterns across the 1.2 Mb region of LD.

Figure 1

A candidate-gene approach to association mapping of the linked region on chromosome 3p21-22 suggests a putative association signal located in a 1.2 Mb region of LD containing over 30 genes. The LD plot of pairwise D′ values, derived from HapMap project data, indicates strong LD across the region (lower panel). Loci in the region tagged by the original study design are indicated on the gene track. The associated region of 336 Kb, as defined by the correlation neighborhood at r2>0.8, along with the replicated SNPs in the region are mapped against the gene track. SNPs in bold were identified in this study, the MST1 coding SNP is boxed, and the reported WTCCC SNP (rs9858542, in BSN) is in normal type.